TB-500

TB-500 is a synthetic peptide derived from Thymosin Beta-4 (Tbeta4), specifically the active fragment Ac-LKKTETQ (residues 17–23). In preclinical research, TB-500 has been studied for its ability to promote cell migration and tissue repair by sequestering G-actin monomers — a process that facilitates cytoskeletal remodelling in injured tissue. Studies in rodent models have investigated applications across muscle and tendon injury recovery, angiogenesis (new blood vessel formation), inflammation reduction, and cardiac tissue research following ischaemic events. Molecular weight: 888.00 Da. For research use only.

Full-length Thymosin Beta-4 (Tbeta4) is a 43-amino acid intracellular protein involved in actin sequestration, wound healing, and inflammation regulation. TB-500 is the smaller active fragment (residues 17–23, sequence Ac-LKKTETQ) that retains the key actin-binding and cell-migration properties of the parent molecule at a fraction of its size (888 Da vs ~4963 Da for full Tbeta4). This makes TB-500 a more focused, accessible research tool for studying the specific actin-mediated repair and angiogenesis mechanisms of Thymosin Beta-4. Not for human consumption — for research use only.

TB-500 and BPC-157 are mechanistically distinct — neither is 'better', they study different aspects of repair. TB-500 works via actin sequestration and cell migration, with a stronger vascular angle (angiogenesis, new blood vessel growth). BPC-157 acts via the NO-system, VEGFR2, and FAK-paxillin pathways, with a stronger focus on localised gut mucosal protection, tendon-to-bone healing, and anti-inflammatory signalling. Because the mechanisms are complementary, combining both is common in tissue repair research — which is why we offer the pre-blended BPC-157 + TB-500 Blend containing 5mg of each. Not for human consumption — for research use only.

Reconstitution: Using a clean 31G insulin syringe, draw 1–2mL of bacteriostatic water. Inject slowly down the inside wall of the TB-500 vial. Gently swirl until fully dissolved — do not shake or vortex. The solution should be clear and colourless. Common concentration: 1mL BAC water = 10mg/mL; 2mL = 5mg/mL. Storage: Lyophilised — store at −20°C for up to 24 months. Reconstituted — refrigerate at 2–8°C and use within 28 days. Protect from light. Our BAC Water 10mL and Insulin Needles 31G are available for a complete setup.

TB-500 is legal to purchase in Australia for legitimate laboratory research purposes. It is not listed as a scheduled substance under the Poisons Standard when sold for research use only. Purchasers must be 18+ and confirm research-only use. It is not TGA-approved for human consumption, therapeutic, or veterinary use. Our TB-500 10mg is independently verified at 99.1% HPLC purity with full COA documentation. Peptide Warehouse Australia dispatches nationwide from our Melbourne warehouse with Australia Post tracking.

Peptide Warehouse Australia dispatches TB-500 10mg nationwide via Australia Post with full tracking from our Melbourne warehouse. Orders placed before 12PM AEST dispatch the same business day; orders after 12PM AEST dispatch the next business day. Standard Post (2–6 business days) $8.99; Express Post (1–3 business days) $13.99. Free shipping on orders over $199 AUD. Discreet plain packaging with no external branding.

While musculoskeletal repair is TB-500's most studied application, preclinical research has also investigated it in: cardiac tissue models — studying actin remodelling and angiogenesis following ischaemic events; ocular surface repair — corneal epithelial wound healing; neurological research — limited studies on neural cell migration; and anti-inflammatory models — suppression of inflammatory mediators in acute injury settings. The breadth of TB-500's research applications stems from the ubiquity of actin dynamics across virtually all cell types. Not for human consumption — for research use only.

TB-500 is a synthetic peptide corresponding to an active region of the naturally occurring protein Thymosin Beta-4 (TB4). Research uses the fragment as a more accessible tool to study the actin-regulation and cell-migration pathways associated with the parent protein. The two are related but not identical. Not for human consumption — for research use only.

TB-500 is studied for its role in actin regulation — binding G-actin and influencing cytoskeletal dynamics — which underlies cell migration, a key step in tissue-repair research models. This mechanism is the basis for its investigation alongside other repair peptides. Not for human consumption — for research use only.

Both are studied in tissue-repair contexts but through different mechanisms: BPC-157 is studied for angiogenesis and localised repair pathways, while TB-500 is studied for actin-mediated cell migration with broader systemic distribution in models. They are frequently examined together as complementary research tools. Not for human consumption — for research use only.

Yes — in research settings TB-500 and BPC-157 are often examined together to probe complementary repair pathways, which is also why a combined BPC-157/TB-500 blend (/products/bpc-157-tb-500-blend) exists. Each is reconstituted separately and combined at the point of use per the protocol. Not for human consumption — for research use only.

TB-500 is a synthetic fragment of Thymosin Beta-4 (TB4). It is also written TB500 or referred to as the Thymosin Beta-4 fragment. For in-vitro research use only.