Epithalon

Epithalon (Epitalon, sequence Ala-Glu-Asp-Gly / AEDG) is a synthetic tetrapeptide modelled on a peptide originally isolated from the pineal gland. In preclinical research it is studied for reported effects on telomerase activity and telomere biology, cellular-ageing and senescence pathways, and pineal regulation of melatonin and circadian rhythm. It is one of the more studied peptides in longevity research. Supplied at ≥99% HPLC purity for in-vitro research use only.

Yes — 'Epithalon' and 'Epitalon' are two spellings of the same tetrapeptide (Ala-Glu-Asp-Gly, AEDG). Both refer to the synthetic pineal-derived research peptide. Our product (CAS 307297-39-8) is supplied at ≥99% HPLC purity with full COA documentation. Not for human consumption — for research use only.

Reconstitution: Add 1–2mL of bacteriostatic water slowly down the inside wall of the vial with a 31G syringe and swirl gently until dissolved; do not shake. A 10mg vial reconstituted with 1mL BAC water yields a 10mg/mL solution. Storage: Lyophilised — store at −20°C for up to 24 months. Reconstituted — refrigerate at 2–8°C and use within 4 weeks, protected from light. BAC water is available at /products/bac-water-10ml. Not for human consumption — for research use only.

Legal status: Epithalon is legal to purchase in Australia for legitimate laboratory research purposes. It is not for human consumption, therapeutic, cosmetic, or veterinary use and is not TGA-approved. Purchasers must be 18+ and confirm research-only intent. Quality: each batch is independently verified by third-party HPLC at ≥99% purity with a full COA including HPLC purity %, mass spectrometry identity confirmation, and sterility screening. Full COAs are available in our COA Library.

Peptide Warehouse Australia stocks Epithalon 10mg and ships nationwide via Australia Post with full tracking. Orders placed before 12PM AEST dispatch the same business day from our Melbourne warehouse; orders after 12PM AEST dispatch the next business day. Standard Post $8.99 (2–6 business days); Express Post $13.99 (1–3 business days); free shipping on all orders over $199 AUD. All orders ship in discreet plain packaging with no external branding. Not for human consumption — for research use only.

The most cited area of Epithalon research is its reported effect on telomerase — the enzyme that maintains telomere length at the ends of chromosomes. In cell-culture studies, Epithalon has been reported to induce telomerase activity and influence telomere length, which is why it is widely used as a research tool in cellular-ageing and senescence models. These findings come from preclinical and in-vitro settings; Epithalon is not approved for human use by the TGA and is supplied strictly for research. Not for human consumption — for research use only.

Epithalon (AEDG) was developed as a synthetic counterpart to a peptide preparation isolated from the pineal gland, and much of the foundational work originates from Russian gerontology research, notably associated with Professor Vladimir Khavinson. It has since appeared in a substantial body of preclinical literature on pineal regulation, circadian rhythm and cellular ageing. This research heritage is part of why Epithalon is a commonly requested longevity-research peptide. Not for human consumption — for research use only.

Because Epithalon is modelled on a pineal-derived peptide, a strand of research examines its influence on the pineal gland's regulation of melatonin secretion and circadian (sleep-wake) rhythm in animal models. This is studied separately from its telomere-related effects and is one reason Epithalon is investigated in ageing models, where circadian and melatonin signalling are of interest. All such work is preclinical and research-only. Not for human consumption — for research use only.

These are different classes of longevity-research tools acting on different pathways. Epithalon (AEDG) is a pineal-derived tetrapeptide studied for telomerase and circadian pathways. NAD+ (/products/nad-plus) supports cellular redox balance and sirtuin-linked pathways. MOTS-c (/products/mots-c) is a mitochondrial-derived peptide acting through AMPK and metabolic signalling. Researchers sometimes compare or combine them to probe complementary aspects of cellular ageing, but they are distinct tools and are not interchangeable. Not for human consumption — for research use only.

Yes — alongside its telomere and pineal research, Epithalon has been examined in preclinical models for effects on oxidative-stress markers and antioxidant defence pathways, which are closely tied to cellular-ageing mechanisms. As with its other studied effects, this work is confined to research models and does not constitute evidence of any human benefit. Not for human consumption — for research use only.

Epithalon is frequently studied in short, defined research cycles rather than continuous exposure, reflecting the protocols used in the published literature, though exact designs vary widely by model and research question. Our 10mg vial supports flexible stock preparation for these protocols. We do not provide dosing guidance — researchers should draw protocol parameters from peer-reviewed sources relevant to their specific experimental design, and can use our peptide calculator (/tools/peptide-calculator) to plan dilutions. Not for human consumption — for research use only.

Epithalon, Epitalon and 'AEDG' all refer to the same synthetic tetrapeptide (Ala-Glu-Asp-Gly, CAS 307297-39-8) that we supply. 'Endoluten' is a separate commercial pineal peptide-bioregulator product and is not the same as our synthetic Epithalon research peptide. If your protocol calls specifically for the synthetic AEDG tetrapeptide, that is what this product is. Not for human consumption — for research use only.