Semax

Semax is a synthetic heptapeptide (sequence: Met-Glu-His-Phe-Pro-Gly-Pro) derived from the ACTH(4-7) fragment of adrenocorticotropic hormone, with a Pro-Gly-Pro extension that increases stability. Originally developed in Russia and extensively studied in Soviet and post-Soviet clinical research, Semax has been investigated in preclinical settings for neuroprotective and neurotrophic effects, BDNF upregulation, cognitive function and memory consolidation models, and ischaemia-related neuroprotection. Its mechanism involves modulation of dopaminergic and serotonergic pathways. Supplied at 99.1% HPLC purity.

Legal status: Semax is legal to purchase in Australia for legitimate laboratory research purposes. It is not listed as a scheduled substance under the Poisons Standard when sold for research use only. Purchasers must be 18+ and confirm research-only intent. Not for human consumption or therapeutic use. Quality: Batch PW-260302, independently verified at 99.1% HPLC purity by an accredited third-party laboratory. COA includes: HPLC purity %, mass spectrometry identity confirmation (MW 813.94 Da), and sterility screening. Full COA available in our COA Library. GMP-certified sourcing with full chain-of-custody documentation.

Reconstitution: Draw 1–2mL of bacteriostatic water into a clean 31G syringe. Inject slowly down the inside wall of the Semax vial and gently swirl until the lyophilised powder is fully dissolved. Do not shake or vortex. The solution should be clear and colourless. A common starting concentration is 1mL BAC water per 10mg vial (10mg/mL), or 2mL for a 5mg/mL working solution. Storage: Lyophilised — store at −20°C for up to 12–24 months, protected from moisture. Reconstituted — refrigerate at 2–8°C and use within 4 weeks. Avoid prolonged room-temperature exposure.

Peptide Warehouse Australia stocks Semax 10mg and ships nationwide via Australia Post with full tracking. Orders placed before 12PM AEST dispatch the same business day from our Melbourne warehouse; orders after 12PM AEST dispatch the next business day. Semax is currently on pre-order with dispatch within 7–10 business days. Shipping rates: Standard Post $8.99 (2–6 business days); Express Post $13.99 (1–3 business days); free shipping on all orders over $199 AUD. All orders are shipped in discreet plain packaging with no external branding.

One of the most studied aspects of Semax in preclinical research is its effect on brain-derived neurotrophic factor (BDNF) expression. In rodent models, Semax has been shown to increase BDNF mRNA expression in the hippocampus and frontal cortex, as well as upregulate expression of BDNF receptor TrkB. BDNF is a key neurotrophin involved in synaptic plasticity, long-term potentiation, and neuronal survival. Semax is also studied for its effects on the expression of other neurotrophins including NGF (nerve growth factor). These BDNF-related mechanisms are the basis for its investigation in ischaemia and cognitive research models. Not for human consumption — for research use only.

Semax and Selank are both Russian-developed synthetic peptides investigated for cognitive and neuroprotective effects, but they have different sequences, mechanisms, and primary research applications. Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is an ACTH analogue primarily studied for BDNF upregulation, neuroprotection in ischaemia models, and dopaminergic pathway modulation. Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a tuftsin analogue primarily studied for anxiolytic effects and serotonergic/GABAergic pathway modulation. They are distinct research tools targeting overlapping but non-identical neurological pathways and are not interchangeable in research protocols. Not for human consumption — for research use only.

Semax has an extensive published research history, particularly from Russian and Eastern European institutions. Key preclinical research areas include: ischaemic stroke models — Semax has been studied for reduction of infarct volume and neurological deficit in rodent middle cerebral artery occlusion (MCAO) models; traumatic brain injury models examining post-injury BDNF expression; optic nerve crush models studying retinal ganglion cell survival; and memory and learning models examining hippocampal plasticity. Semax has also been investigated in human clinical research in Russia, where it is registered as a nasal drug (not a scheduled pharmaceutical in Australia). Not for human consumption — for research use only.

In research settings, Semax is sometimes studied alongside other neuroactive peptides to examine additive or synergistic effects on neurological pathways. Combinations with Selank (for complementary anxiolytic/nootropic pathway coverage) or with NAD+ (for mitochondrial and neuroprotective research) represent areas of interest in the literature. Each compound should be reconstituted separately in its own vial using BAC water from /products/bac-water-10ml and combined at the point of use if required by the protocol. Researchers should consult published literature for appropriate concentration ratios. Not for human consumption — for research use only.

No. Semax (Met-Glu-His-Phe-Pro-Gly-Pro) and N-acetyl Semax are distinct chemical entities. N-acetyl Semax has an acetyl group added to the N-terminus of the Semax sequence, which alters its physicochemical properties, receptor binding profile, and stability characteristics. Similarly, N-acetyl Semax Amidate adds both an N-terminal acetyl group and a C-terminal amide — producing a further distinct compound. Our product is unmodified Semax (CAS 80714-61-0). Researchers should confirm which specific analogue their protocol requires before ordering. Not for human consumption — for research use only.

As a peptide, Semax is sensitive to heat, light and repeated freeze-thaw cycles. Store the lyophilised vial at −20°C, and once reconstituted keep it refrigerated at 2–8°C, protected from light, using it within about 4 weeks. Minimising temperature fluctuation preserves peptide integrity for research. Not for human consumption — for research use only.

Working concentrations are protocol-dependent and vary by model. A 10mg vial reconstituted in 1mL of bacteriostatic water yields a 10mg/mL stock that researchers dilute to their target concentration. We provide no dosing guidance — consult the literature for your model and use our peptide calculator (/tools/peptide-calculator) to plan dilutions. Not for human consumption — for research use only.

Semax is a research nootropic peptide derived from a fragment of ACTH(4-10). It is occasionally written Semaks and is studied alongside its close relative Selank. For in-vitro research use only.