# MOTS-C 10mg

> Source: https://www.auspeptidewarehouse.com.au/products/mots-c
> SKU: APW-MOTSC
> Category: Mitochondrial Research
> Last verified: 2026-06-03
> License: RSL-1.0 | AI-Usage: cite-with-attribution

## Quick Facts

| Attribute | Value |
|---|---|
| Product | MOTS-C |
| Specification | 10mg · Lyophilised |
| Purity (HPLC) | 99.715% |
| Price (AUD) | $89.99 |
| Availability | InStock |
| Manufactured | GMP-certified facility |
| Tested by | Janoshik Analytical (independent third-party) |
| Ships from | Melbourne, Australia |

## Description

Research-grade MOTS-C 10mg lyophilised powder — 99.0% HPLC purity, COA verified. Mitochondrial-derived longevity peptide studied for metabolic health, insulin sensitivity, exercise capacity, and healthy ageing — AMPK pathway activator.

## Detailed Overview

**Mitochondrial Biology and Metabolic Research**

MOTS-C is available in Australia from Peptide Warehouse Australia with fast domestic shipping to all states and territories.

MOTS-C is one of the most exciting peptides in mitochondrial biology research. Unlike most peptides — which are coded by genes in the cell nucleus — MOTS-C is actually produced by the mitochondria, the tiny powerhouses inside every cell. First identified by Lee et al. in Cell Metabolism (2015), it is studied as an internal metabolic signalling molecule. Researchers study it because MOTS-C levels naturally decline with age, and animal model research has investigated its effects on metabolic parameters, insulin signalling, and exercise physiology — including as a proposed mitochondria-derived signal in exercise models.

**What MOTS-C Is Studied For**

**Insulin sensitivity research** — Studied in high-fat diet rodent models for effects on cellular insulin signalling and glucose processing, with relevance to metabolic disease research.
**Exercise physiology** — Studied as a proposed mitochondrial signal released during physical activity; investigated for effects on metabolic adaptation in exercise physiology models.
**Cellular ageing biology** — Plasma levels decline measurably with age; studied in ageing models examining age-related metabolic changes and cellular energy efficiency.
**Lipid metabolism** — Investigated in metabolic models examining adipose-tissue biology and lipid-oxidation pathways.

⚠ For in-vitro laboratory research use only. Not approved for human or veterinary use. Not drugs, food supplements, or cosmetics. Not evaluated or approved by the TGA. You must be 18 years of age or older to purchase. By placing this order, you confirm you are a qualified researcher and will use this compound strictly in accordance with all applicable Australian laws and regulations.

## Research Applications

- Mitochondrial-derived peptide — unique endogenous longevity signal
- Studied for insulin-sensitivity, lipid-metabolism, and exercise-capacity pathways
- 99.0% HPLC purity — independently verified
- Full COA with mass spectrometry confirmation
- GMP-certified sourcing, sterility screened
- AMPK pathway activator — studied in metabolic syndrome and ageing models

## Shipping

- Standard Post: $8.99 AUD (2–6 business days)
- Express Post: $13.99 AUD (1–3 business days)
- Free shipping on orders over $199 AUD
- Orders placed before 12PM AEST dispatch the same business day; orders after 12PM AEST dispatch the next business day
- Discreet plain packaging, Australia Post tracking on every order

## Frequently Asked Questions

### What is MOTS-C and what does the research show?

MOTS-C (CAS 1457116-20-9, MW 2174.59 Da) is a 16-amino acid peptide encoded within the 12S rRNA region of the mitochondrial genome — not the nuclear genome like most peptide hormones. First identified at the University of Southern California in 2015, MOTS-C has been studied for: improving insulin sensitivity and glucose uptake in high-fat diet rodent models, activating AMPK (the master cellular energy regulator) under metabolic stress, improving exercise tolerance and endurance capacity in preclinical models, examining age-related metabolic changes (plasma MOTS-C levels fall with age), examining adipose-tissue biology in metabolic models, and extending lifespan in C. elegans models. For research use only.

### What makes MOTS-C different from other longevity peptides like Epitalon or NAD+?

MOTS-C, Epitalon, and NAD+ address ageing through entirely different biological mechanisms. MOTS-C is a mitochondria-derived peptide that activates AMPK via nuclear translocation — directly improving cellular energy metabolism and insulin sensitivity. Epitalon is a tetrapeptide that activates telomerase, with longevity research focused on telomere length and circadian biology. NAD+ is a coenzyme (not a peptide) that supports mitochondrial ATP production and sirtuins as a substrate. Each targets a different aspect of the ageing process and they are not interchangeable research tools. Not for human consumption — for research use only.

### What is the AMPK pathway and why is MOTS-C's activation of it significant?

AMPK (AMP-activated protein kinase) is the cell's master energy sensor. When cellular energy is low or under metabolic stress, AMPK is activated and triggers increased glucose uptake and fatty acid oxidation, inhibition of energy-consuming processes, improved mitochondrial biogenesis, and downregulation of inflammatory pathways. Under metabolic stress, MOTS-C translocates from the mitochondria to the cell nucleus and activates AMPK directly — an unusual signalling mechanism for a mitochondrial peptide. This nuclear translocation and AMPK activation is the primary proposed mechanism behind MOTS-C's observed effects on insulin sensitivity, fat metabolism, and exercise capacity. Not for human consumption — for research use only.

### How does MOTS-C relate to exercise in research models?

One of the key findings in MOTS-C research is that physical exercise dynamically increases circulating MOTS-C levels in rodent models. In reciprocal experiments, MOTS-C administration to sedentary animals replicated some metabolic adaptations normally seen with exercise training — including improved glucose tolerance, increased skeletal muscle fatty acid utilisation, and enhanced endurance capacity. This has led researchers to propose MOTS-C as a potential 'exercise mimetic' — a signal the body normally releases in response to exercise-induced mitochondrial stress. Not for human consumption — for research use only.

### How do I reconstitute and store MOTS-C 10mg?

Reconstitution: Draw 1–2mL of bacteriostatic water into a clean 31G insulin syringe. Inject slowly down the inside wall of the MOTS-C vial. Gently swirl until fully dissolved. The solution should be clear and colourless. Common concentration: 1mL BAC water = 10mg/mL; 2mL = 5mg/mL. Storage: Lyophilised — store at −20°C for up to 24 months. Reconstituted — refrigerate at 2–8°C and use within 28 days. Protect from light.

### Is MOTS-C legal to buy in Australia?

MOTS-C is legal to purchase in Australia for legitimate laboratory research purposes. It is not listed as a scheduled substance under the Poisons Standard when sold for research use only. Purchasers must be 18+ and confirm research-only use. It is not TGA-approved for human consumption, therapeutic, or veterinary use. Our MOTS-C 10mg is independently verified at 99.0% HPLC purity with full COA documentation. Peptide Warehouse Australia dispatches nationwide from our Australian warehouse via Australia Post.

## Compliance

Sold strictly for in-vitro laboratory and research purposes only. Not for human consumption, therapeutic use, or veterinary use. Purchasers must be 18 years of age or older. See https://www.auspeptidewarehouse.com.au/legal for full terms.